diff --git a/src/test/java/com/android/tools/r8/ir/optimize/interfaces/OpenInterfaceInstanceofTest.java b/src/test/java/com/android/tools/r8/ir/optimize/interfaces/OpenInterfaceInstanceofTest.java
new file mode 100644
index 0000000..d73550c
--- /dev/null
+++ b/src/test/java/com/android/tools/r8/ir/optimize/interfaces/OpenInterfaceInstanceofTest.java
@@ -0,0 +1,137 @@
+// Copyright (c) 2022, the R8 project authors. Please see the AUTHORS file
+// for details. All rights reserved. Use of this source code is governed by a
+// BSD-style license that can be found in the LICENSE file.
+
+package com.android.tools.r8.ir.optimize.interfaces;
+
+import static org.junit.Assert.assertEquals;
+import static org.junit.Assume.assumeTrue;
+
+import com.android.tools.r8.NeverInline;
+import com.android.tools.r8.NoVerticalClassMerging;
+import com.android.tools.r8.TestBase;
+import com.android.tools.r8.TestParameters;
+import com.android.tools.r8.TestParametersCollection;
+import com.android.tools.r8.ToolHelper.DexVm.Version;
+import com.google.common.collect.ImmutableList;
+import java.io.IOException;
+import java.util.List;
+import org.junit.Test;
+import org.junit.runner.RunWith;
+import org.junit.runners.Parameterized;
+import org.junit.runners.Parameterized.Parameter;
+import org.junit.runners.Parameterized.Parameters;
+import org.objectweb.asm.Opcodes;
+
+@RunWith(Parameterized.class)
+public class OpenInterfaceInstanceofTest extends TestBase {
+
+  @Parameter(0)
+  public TestParameters parameters;
+
+  @Parameters(name = "{0}")
+  public static TestParametersCollection data() {
+    return getTestParameters().withAllRuntimesAndApiLevels().build();
+  }
+
+  @Test
+  public void testJvm() throws Exception {
+    assumeTrue(parameters.isCfRuntime());
+    testForRuntime(parameters)
+        .addProgramClasses(getProgramClasses())
+        .addProgramClassFileData(getTransformedMainClass())
+        .run(parameters.getRuntime(), Main.class)
+        .assertSuccessWithOutputLines(getExpectedOutputLines(false));
+  }
+
+  @Test
+  public void testD8() throws Exception {
+    assumeTrue(parameters.isDexRuntime());
+    testForD8(parameters.getBackend())
+        .addProgramClasses(getProgramClasses())
+        .addProgramClassFileData(getTransformedMainClass())
+        .setMinApi(parameters.getApiLevel())
+        .run(parameters.getRuntime(), Main.class)
+        .assertSuccessWithOutputLines(getExpectedOutputLines(false));
+  }
+
+  @Test
+  public void testR8() throws Exception {
+    testForR8(parameters.getBackend())
+        .addProgramClasses(getProgramClasses())
+        .addProgramClassFileData(getTransformedMainClass())
+        .addKeepMainRule(Main.class)
+        .enableInliningAnnotations()
+        // TODO(b/214496607): I should not be merged into A in the first place, since I is open.
+        .enableNoVerticalClassMergingAnnotations()
+        .setMinApi(parameters.getApiLevel())
+        .run(parameters.getRuntime(), Main.class)
+        .assertSuccessWithOutputLines(getExpectedOutputLines(true));
+  }
+
+  private List<Class<?>> getProgramClasses() {
+    return ImmutableList.of(I.class, A.class, B.class);
+  }
+
+  private byte[] getTransformedMainClass() throws IOException {
+    return transformer(Main.class)
+        .transformTypeInsnInMethod(
+            "getB",
+            (opcode, type, visitor) -> {
+              assertEquals(opcode, Opcodes.NEW);
+              assertEquals(type, binaryName(A.class));
+              visitor.visitTypeInsn(opcode, binaryName(B.class));
+            })
+        .transformMethodInsnInMethod(
+            "getB",
+            (opcode, owner, name, descriptor, isInterface, visitor) -> {
+              assertEquals(opcode, Opcodes.INVOKESPECIAL);
+              assertEquals(owner, binaryName(A.class));
+              assertEquals(name, "<init>");
+              visitor.visitMethodInsn(opcode, binaryName(B.class), name, descriptor, isInterface);
+            })
+        .transform();
+  }
+
+  private List<String> getExpectedOutputLines(boolean isR8) {
+    if (isR8) {
+      // TODO(b/214496607): R8 should not optimize the instanceof instruction since I is open.
+      return ImmutableList.of("true", "true");
+    }
+    if (parameters.isDexRuntime() && parameters.getDexRuntimeVersion().isEqualTo(Version.V7_0_0)) {
+      return ImmutableList.of("true", "true");
+    }
+    return ImmutableList.of("true", "false");
+  }
+
+  static class Main {
+
+    public static void main(String[] args) {
+      System.out.println(isIOrNull(getA()));
+      System.out.println(isIOrNull(getB()));
+    }
+
+    @NeverInline
+    static boolean isIOrNull(I i) {
+      if (i != null) {
+        return i instanceof I;
+      }
+      return true;
+    }
+
+    static I getA() {
+      return new A();
+    }
+
+    static I getB() {
+      return new A(); // transformed into new B().
+    }
+  }
+
+  @NoVerticalClassMerging
+  interface I {}
+
+  static class A implements I {}
+
+  static class B {}
+}
diff --git a/src/test/java/com/android/tools/r8/ir/optimize/interfaces/OpenUninstantiatedInterfaceInstanceofTest.java b/src/test/java/com/android/tools/r8/ir/optimize/interfaces/OpenUninstantiatedInterfaceInstanceofTest.java
new file mode 100644
index 0000000..7740192
--- /dev/null
+++ b/src/test/java/com/android/tools/r8/ir/optimize/interfaces/OpenUninstantiatedInterfaceInstanceofTest.java
@@ -0,0 +1,127 @@
+// Copyright (c) 2022, the R8 project authors. Please see the AUTHORS file
+// for details. All rights reserved. Use of this source code is governed by a
+// BSD-style license that can be found in the LICENSE file.
+
+package com.android.tools.r8.ir.optimize.interfaces;
+
+import static org.junit.Assert.assertEquals;
+import static org.junit.Assume.assumeTrue;
+
+import com.android.tools.r8.NeverInline;
+import com.android.tools.r8.TestBase;
+import com.android.tools.r8.TestParameters;
+import com.android.tools.r8.TestParametersCollection;
+import com.android.tools.r8.ToolHelper.DexVm.Version;
+import com.google.common.collect.ImmutableList;
+import java.io.IOException;
+import java.util.List;
+import org.junit.Test;
+import org.junit.runner.RunWith;
+import org.junit.runners.Parameterized;
+import org.junit.runners.Parameterized.Parameter;
+import org.junit.runners.Parameterized.Parameters;
+import org.objectweb.asm.Opcodes;
+
+@RunWith(Parameterized.class)
+public class OpenUninstantiatedInterfaceInstanceofTest extends TestBase {
+
+  @Parameter(0)
+  public TestParameters parameters;
+
+  @Parameters(name = "{0}")
+  public static TestParametersCollection data() {
+    return getTestParameters().withAllRuntimesAndApiLevels().build();
+  }
+
+  @Test
+  public void testJvm() throws Exception {
+    assumeTrue(parameters.isCfRuntime());
+    testForRuntime(parameters)
+        .addProgramClasses(getProgramClasses())
+        .addProgramClassFileData(getTransformedMainClass())
+        .run(parameters.getRuntime(), Main.class)
+        .assertSuccessWithOutputLines(getExpectedOutputLines(false));
+  }
+
+  @Test
+  public void testD8() throws Exception {
+    assumeTrue(parameters.isDexRuntime());
+    testForD8(parameters.getBackend())
+        .addProgramClasses(getProgramClasses())
+        .addProgramClassFileData(getTransformedMainClass())
+        .setMinApi(parameters.getApiLevel())
+        .run(parameters.getRuntime(), Main.class)
+        .assertSuccessWithOutputLines(getExpectedOutputLines(false));
+  }
+
+  @Test
+  public void testR8() throws Exception {
+    testForR8(parameters.getBackend())
+        .addProgramClasses(getProgramClasses())
+        .addProgramClassFileData(getTransformedMainClass())
+        .addKeepMainRule(Main.class)
+        .enableInliningAnnotations()
+        .setMinApi(parameters.getApiLevel())
+        .run(parameters.getRuntime(), Main.class)
+        .assertSuccessWithOutputLines(getExpectedOutputLines(true));
+  }
+
+  private List<Class<?>> getProgramClasses() {
+    return ImmutableList.of(I.class, A.class, B.class);
+  }
+
+  private byte[] getTransformedMainClass() throws IOException {
+    return transformer(Main.class)
+        .transformTypeInsnInMethod(
+            "getB",
+            (opcode, type, visitor) -> {
+              assertEquals(opcode, Opcodes.NEW);
+              assertEquals(type, binaryName(A.class));
+              visitor.visitTypeInsn(opcode, binaryName(B.class));
+            })
+        .transformMethodInsnInMethod(
+            "getB",
+            (opcode, owner, name, descriptor, isInterface, visitor) -> {
+              assertEquals(opcode, Opcodes.INVOKESPECIAL);
+              assertEquals(owner, binaryName(A.class));
+              assertEquals(name, "<init>");
+              visitor.visitMethodInsn(opcode, binaryName(B.class), name, descriptor, isInterface);
+            })
+        .transform();
+  }
+
+  private List<String> getExpectedOutputLines(boolean isR8) {
+    if (isR8) {
+      // TODO(b/214496607): R8 should not optimize the instanceof instruction since I is open.
+      return ImmutableList.of("true");
+    }
+    if (parameters.isDexRuntime()) {
+      if (parameters.getDexRuntimeVersion().isEqualTo(Version.V7_0_0)
+          || parameters.getDexRuntimeVersion().isEqualTo(Version.V13_MASTER)) {
+        return ImmutableList.of("true");
+      }
+    }
+    return ImmutableList.of("false");
+  }
+
+  static class Main {
+
+    public static void main(String[] args) {
+      I b = getB();
+      if (b != null) {
+        System.out.println(b instanceof I);
+      }
+    }
+
+    @NeverInline
+    static I getB() {
+      return new A(); // transformed into new B().
+    }
+  }
+
+  interface I {}
+
+  static class A implements I {}
+
+  static class B {}
+}