diff --git a/src/main/java/com/android/tools/r8/graph/AppInfo.java b/src/main/java/com/android/tools/r8/graph/AppInfo.java
index 7997cea..7ffcf30 100644
--- a/src/main/java/com/android/tools/r8/graph/AppInfo.java
+++ b/src/main/java/com/android/tools/r8/graph/AppInfo.java
@@ -226,7 +226,7 @@
       return null;
     }
     DexEncodedMethod singleTarget = invocationContext.lookupDirectMethod(method);
-    if (singleTarget.isStatic()) {
+    if (singleTarget != null && singleTarget.isStatic()) {
       return singleTarget;
     }
     return null;
@@ -250,7 +250,7 @@
       return null;
     }
     DexEncodedMethod singleTarget = invocationContext.lookupDirectMethod(method);
-    if (!singleTarget.isStatic()) {
+    if (singleTarget != null && !singleTarget.isStatic()) {
       return singleTarget;
     }
     return null;