diff --git a/src/test/java/com/android/tools/r8/ir/optimize/canonicalization/InstanceGetOnCheckCastCompareLongTest.java b/src/test/java/com/android/tools/r8/ir/optimize/canonicalization/InstanceGetOnCheckCastCompareLongTest.java
new file mode 100644
index 0000000..c2721f1
--- /dev/null
+++ b/src/test/java/com/android/tools/r8/ir/optimize/canonicalization/InstanceGetOnCheckCastCompareLongTest.java
@@ -0,0 +1,130 @@
+// Copyright (c) 2022, the R8 project authors. Please see the AUTHORS file
+// for details. All rights reserved. Use of this source code is governed by a
+// BSD-style license that can be found in the LICENSE file.
+
+package com.android.tools.r8.ir.optimize.canonicalization;
+
+import static org.hamcrest.CoreMatchers.containsString;
+import static org.junit.Assert.assertThrows;
+
+import com.android.tools.r8.CompilationFailedException;
+import com.android.tools.r8.NeverInline;
+import com.android.tools.r8.R8FullTestBuilder;
+import com.android.tools.r8.TestBase;
+import com.android.tools.r8.TestParameters;
+import com.android.tools.r8.TestParametersCollection;
+import com.android.tools.r8.utils.AndroidApiLevel;
+import org.junit.Test;
+import org.junit.runner.RunWith;
+import org.junit.runners.Parameterized;
+import org.junit.runners.Parameterized.Parameter;
+import org.junit.runners.Parameterized.Parameters;
+import org.objectweb.asm.Opcodes;
+
+/** This is a regression test for b/251015885. */
+@RunWith(Parameterized.class)
+public class InstanceGetOnCheckCastCompareLongTest extends TestBase {
+
+  private final String EXPECTED = "Hello World!";
+
+  @Parameter(0)
+  public TestParameters parameters;
+
+  @Parameters(name = "{0}")
+  public static TestParametersCollection data() {
+    return getTestParameters().withDexRuntimesAndAllApiLevels().build();
+  }
+
+  @Test
+  public void testRuntime() throws Exception {
+    testForRuntime(parameters)
+        .addProgramClasses(I.class, Main.class)
+        .addProgramClassFileData(getTestClassWithRewrittenLongCompareToLCmp())
+        .run(parameters.getRuntime(), Main.class)
+        .assertSuccessWithOutputLines(EXPECTED);
+  }
+
+  @Test
+  public void testR8() throws Exception {
+    // For R8 we will try to shorten the live range and we have a bailout to find an insertion
+    // point if we see a cmp instruction and the api is lower than 23. The receiver of the instance
+    // get is not defined on the insertion point which is why this regression test was made.
+    R8FullTestBuilder r8FullTestBuilder =
+        testForR8(parameters.getBackend())
+            .addProgramClasses(I.class, Main.class)
+            .addProgramClassFileData(getTestClassWithRewrittenLongCompareToLCmp())
+            .addKeepMainRule(Main.class)
+            .addKeepClassRules(I.class)
+            .setMinApi(parameters.getApiLevel())
+            .enableInliningAnnotations();
+    if (parameters.getApiLevel().isLessThan(AndroidApiLevel.M)) {
+      // TODO(b/251015885). We should not fail compilation.
+      assertThrows(
+          CompilationFailedException.class,
+          () ->
+              r8FullTestBuilder.compileWithExpectedDiagnostics(
+                  diagnostics ->
+                      diagnostics.assertErrorMessageThatMatches(
+                          containsString("Unexpected values live at entry to first block"))));
+
+    } else {
+      r8FullTestBuilder
+          .run(parameters.getRuntime(), Main.class)
+          .assertSuccessWithOutputLines(EXPECTED);
+    }
+  }
+
+  private byte[] getTestClassWithRewrittenLongCompareToLCmp() throws Exception {
+    return transformer(TestClass.class)
+        .transformMethodInsnInMethod(
+            "test",
+            (opcode, owner, name, descriptor, isInterface, visitor) -> {
+              if (name.equals("compare")) {
+                visitor.visitInsn(Opcodes.LCMP);
+              } else {
+                visitor.visitMethodInsn(opcode, owner, name, descriptor, isInterface);
+              }
+            })
+        .transform();
+  }
+
+  interface I {
+
+    boolean isTrue();
+  }
+
+  public static class TestClass {
+    @NeverInline
+    public static boolean test(Long longValue, I object) {
+      if (object != null) {
+        long longVal = longValue;
+        // Compiling with JDK8 produces LCMP where JDK 11 keeps the method call. We need LCMP.
+        int compare = Long.compare(longVal, 0L); // <-- will be LCMP after transforming.
+        Main main = (Main) object;
+        boolean otherVal = main.field;
+        if (compare != 0) {
+          return otherVal;
+        } else {
+          return !otherVal;
+        }
+      }
+      return false;
+    }
+  }
+
+  static class Main implements I {
+
+    final boolean field = System.currentTimeMillis() > 0;
+
+    public static void main(String[] args) {
+      if (TestClass.test(System.currentTimeMillis(), new Main())) {
+        System.out.println("Hello World!");
+      }
+    }
+
+    @Override
+    public boolean isTrue() {
+      return field;
+    }
+  }
+}