diff --git a/src/test/java/com/android/tools/r8/classmerging/vertical/VerticalClassMergingWithMissingTypeArgsSubstitutionTest.java b/src/test/java/com/android/tools/r8/classmerging/vertical/VerticalClassMergingWithMissingTypeArgsSubstitutionTest.java
new file mode 100644
index 0000000..50a658f
--- /dev/null
+++ b/src/test/java/com/android/tools/r8/classmerging/vertical/VerticalClassMergingWithMissingTypeArgsSubstitutionTest.java
@@ -0,0 +1,83 @@
+// Copyright (c) 2022, the R8 project authors. Please see the AUTHORS file
+// for details. All rights reserved. Use of this source code is governed by a
+// BSD-style license that can be found in the LICENSE file.
+
+package com.android.tools.r8.classmerging.vertical;
+
+import static org.junit.Assert.assertThrows;
+
+import com.android.tools.r8.CompilationFailedException;
+import com.android.tools.r8.DiagnosticsMatcher;
+import com.android.tools.r8.NeverInline;
+import com.android.tools.r8.TestBase;
+import com.android.tools.r8.TestParameters;
+import com.android.tools.r8.TestParametersCollection;
+import com.android.tools.r8.utils.ExceptionDiagnostic;
+import java.lang.reflect.TypeVariable;
+import org.junit.Test;
+import org.junit.runner.RunWith;
+import org.junit.runners.Parameterized;
+import org.junit.runners.Parameterized.Parameter;
+import org.junit.runners.Parameterized.Parameters;
+
+@RunWith(Parameterized.class)
+public class VerticalClassMergingWithMissingTypeArgsSubstitutionTest extends TestBase {
+
+  @Parameter(0)
+  public TestParameters parameters;
+
+  @Parameters(name = "{0}")
+  public static TestParametersCollection data() {
+    return getTestParameters().withAllRuntimesAndApiLevels().build();
+  }
+
+  @Test()
+  public void test() throws Exception {
+    assertThrows(
+        CompilationFailedException.class,
+        () -> {
+          testForR8Compat(parameters.getBackend())
+              .addInnerClasses(getClass())
+              .addKeepMainRule(Main.class)
+              .addKeepClassRules(A.class)
+              .addKeepAttributeSignature()
+              .addVerticallyMergedClassesInspector(
+                  inspector -> inspector.assertMergedIntoSubtype(B.class))
+              .enableInliningAnnotations()
+              .setMinApi(parameters.getApiLevel())
+              .compileWithExpectedDiagnostics(
+                  diagnostics ->
+                      diagnostics.assertErrorsMatch(
+                          DiagnosticsMatcher.diagnosticType(ExceptionDiagnostic.class)));
+        });
+  }
+
+  static class Main {
+
+    public static void main(String[] args) {
+      C<String> stringC = new C<>();
+      for (TypeVariable<? extends Class<? extends C>> typeParameter :
+          stringC.getClass().getTypeParameters()) {
+        System.out.println(typeParameter.getName());
+      }
+      stringC.m("Hello World");
+    }
+  }
+
+  static class A<T> {}
+
+  static class B<T> extends A<T> {
+
+    @NeverInline
+    public T foo(T t) {
+      return t;
+    }
+  }
+
+  static class C<T> extends B {
+
+    void m(T t) {
+      System.out.println(foo(t));
+    }
+  }
+}